1. Modified big‐bubble technique compared to manual dissection deep anterior lamellar keratoplasty in the treatment of keratoconus
- Author
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Paolo Rama, Karl Anders Knutsson, Giorgio Paganoni, Knutsson, Ka, Rama, P, and Paganoni, G
- Subjects
Adult ,Male ,Keratoconus ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Corneal Stroma ,Visual Acuity ,Lamellar keratoplasty ,Cell Count ,Refraction, Ocular ,Corneal Transplantation ,Young Adult ,Manual dissection ,Suture (anatomy) ,medicine ,Humans ,In patient ,Prospective Studies ,business.industry ,Dissection ,Endothelium, Corneal ,Corneal Topography ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Endothelial cell density ,Ophthalmology ,Female ,medicine.symptom ,business - Abstract
Purpose To evaluate the clinical findings and results of manual dissection deep anterior lamellar keratoplasty (DALK) compared to a modified big-bubble DALK technique in eyes affected by keratoconus. Methods Sixty eyes of 60 patients with keratoconus were treated with one of the two surgical techniques manual DALK (n = 30); big-bubble DALK (n = 30). The main outcomes measured were visual acuity, corneal topographic parameters, thickness of residual stroma and endothelial cell density (ECD). Patients were examined postoperatively at 1 month, 6 months, 1 year and 1 month after suture removal. Results Final best spectacle-corrected visual acuity (BSCVA) measured 1 month after suture removal was 0.11 ± 0.08 LogMAR in the big-bubble group compared to 0.13 ± 0.08 in the manual DALK group (p = 0.227). In patients treated with the big-bubble technique without complications (Descemet's membrane completely bared), the stromal residue was not measureable. Mean stromal residual thickness in the manual DALK group was 30.50 ± 27.60 μm. Data analysis of the manual DALK group demonstrated a significant correlation between BSCVA and residual stromal thickness; lower residual stromal thickness correlated with better BSCVA values (Spearman ρ = 0.509, p = 0.018). Postoperative ECD was similar in both groups at all intervals, with no statistically significant differences. In both groups, ECD loss was only significant during the 1- to 6-month interval (p = 0.001 and p
- Published
- 2015