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Purpose To study macular involvement in non infectious intermediate, posterior and panuveitis. Methods The data of 201 eyes in 118 patients with diagnosed non infectious intermediate, posterior or panuveitis examined between January 2007 and June 2012 were retrospectively reviewed. All patients underwent complete ophthalmic examination with fluorescein angiography and optical coherence tomography (OCT) to assess macular involvement. Results Uveitis was due to behcet's disease in 62 eyes(30.8%), sarcoidosis in 22 eyes (10.9%), VKH in 24 eyes (11.9%), sympathetic ophthalmia in 1 eye (0.5%), birdshot chorioretinopathy in 2 eyes (1%), and multiple sclerosis in 2 eyes (1%). At initial examination, 54 eyes (27.2%) demonstrated macular involvement which consisted in macular edema (ME) in 32 eyes (15.9%), serous retinal detachment in 29 eyes(14.4%), epiretinal membrane (ERM) in 8 eyes (3.9%), macular atrophy in 2 eyes (1%), vitreo‐retinal traction in 1 eye (0.5%), macular hole in 1 eye (0.5%) , and active macular chorioretinitis in 1 eye (0.5%). During follow up, 16 eyes (8%) developed macular complications including ME in 6 eyes(3%), ERM in 5 eyes (2.5%), and macular atrophy in 5 eyes (2.5%). Conclusion Macular involvement,especially macular edema, is common in non infectious intermediate, posterior and panuveitis. It may lead to irreversible visual impairment. Thus, recognition of macular morphological characteristics by performing both OCT and fluorescein angiography in uveitic disease may facilitate earlier diagnosis and the initiation of specific treatment. [ABSTRACT FROM AUTHOR]

Purpose To evaluate the prognostic factors for visual outcome after intravitreal bevacizumab injection in patients with pigment epithelial detachment (PED) in AMD Methods Thirty eyes in 30 patients with CNV and PED in AMD who had received intravitreal bevacizumab injections were retrospectively reviewed. Initial visual acuity, pigment epithelial detachment size, retinal or subretinal fluid resolution and CNV location were evaluated at 12 months. Results Initial visual acuity was not correlated with BCVA at 12 months (p=0.063). CNV at the edge of PED appears to respond more favorably at 12 months (p=0.033) than CNV within PED. Sub and intraretinal fluid initially resolved faster than the sub‐PED fluid (P = 0.041).The subretinal pigment epithelial fluid was highly resistant. Sub and intraretinal fluid response did not appear to be related to PED size. Visual acuity improvement was similar in both groups: large and minimal PED component. Conclusion The location of CNV and the retinal or subretinal fluid resolution were the main prognostic factors for visual outcome. Bevacizumab was very effective in reducing more of the sub‐ and intraretinal fluid than the PED fluid in AMD with CNV. [ABSTRACT FROM AUTHOR]

Purpose To investigate the morphologic alterations around the optic disc by SD‐OCT with high myopia Methods One hundred eyes (54 patients) with high myopia (>‐6.00 diopters) were included. The participants had ophthalmologic examinations including stereoscopic fundus observations, OCT examinations. For OCT, multiple horizontal and vertical and cercle scans were obtained around the optic disc and fovea in each patient. Results Patients were mean age 43.2+/‐9.4 years, with a spherical‐equivalent refractive error of ‐11.26+/‐4.85 D and mean axial length of 27.65+/‐1.82 mm. A peripapillary detachment was detected by OCT in 8 eyes (8%) as a hyporeflective space intrachoroidally and subretinally. It was also observed within the tissue posterior to the conus in eyes without the typical ophthalmoscopic yellow‐orange lesions. Microfolds in the retinal vessels were detected at the conus edge in 40 of the highly myopic eyes (40%), and 10 of these eyes had paravascular cysts (10%). A retinoschisis was present at the site of the retinal vessels in 10 eyes (10%). Conclusion The SD OCT examinations demonstrated different types of peripapillary changes in highly myopic eyes. It is important to detect these peripapillary changes especially peripapillary detachment by OCT to be able to predict the later development of visually disabling conditions. [ABSTRACT FROM AUTHOR]

Purpose to measure macular choroidal thickness (CT) using spectral domain optical coherence tomography (OCT) and to investigate the correlation between CT and age, degree of myopia, and a history of macular choroidal neovascularization (CNV). Methods a cross sectional study was performed in 191 eyes of 106 patients with spherical equivalent (SE) refractive error of 6 diopters (D) or more, between early January 2010 and early June 2010. The choroid was imaged using the spectral domain OCT (OCT TOPCON 2000) by changing the reference position from the vitreous to the choroid without inverting the image. CT was measured from the outer border of the hyperreflective line corresponding to the retinal pigment epithelium (RPE) to the inner scleral border. Results the mean age of the 106 patients was 47,9 years (± 14,89 years; range, 18 to 81 years), 32 were men and 74 were women, the mean SE refractive error was 13,73 D (±5,74 D), and the mean subfoveal CT was 100,42 µm (±60,15µm; range, 23‐278). CT was correlated negatively with age (p= 0,01), and refractive error (p=0,01). Fourty eyes had a history of CNV, the mean CT was 52,02 ± 17,65 µm, and this was significantly thinner than the subgroup without CNV (p<0,10‐6). Conclusion in highly myopic eyes, the choroid is thin and undergoes further attenuation with increasing age and increasing myopia. In addition, these findings suggest that the choroid may play a role in the pathogenesis of choroidal neovascularization. [ABSTRACT FROM AUTHOR]