1. Monoamine receptors in human corneal epithelium and endothelium.
- Author
-
Grueb M, Wallenfels-Thilo B, Denk O, Mielke J, Reinthal E, Rohrbach JM, and Bartz-Schmidt KU
- Subjects
- Adult, Aged, Blotting, Western, Female, Fluorescent Antibody Technique, Indirect, Humans, Immunoblotting, Immunohistochemistry, Male, Middle Aged, Endothelium, Corneal metabolism, Epithelium, Corneal metabolism, Receptors, Adrenergic metabolism, Receptors, Dopamine metabolism, Receptors, Serotonin metabolism
- Abstract
Purpose: Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent., Methods: Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and endothelium., Results: Antibodies to alpha-1, beta-1 and beta-2 adrenergic receptors and to D1-like and 5HT-7 receptors were bound in corneal epithelium. Antibodies to alpha-1, alpha-2A, beta-1 and beta-2 adrenergic receptors and to 5HT-7 receptors were bound in corneal endothelium., Conclusions: Our data demonstrate the presence of several monoamine receptors in the human cornea. These receptors may play a role in the regulation of fluid transport or corneal homeostasis.
- Published
- 2006
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