1. Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis.
- Author
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Guilemany, Jose Maria, Alós, Llucia, Alobid, Isam, Bernal-Sprekelsen, Manuel, and Cardesa, Antonio
- Subjects
LARYNGEAL tumors ,TRACHEOTOMY ,TRACHEAL diseases ,OTOLARYNGOLOGY - Abstract
Inflammatory myofibroblastic tumor is extremely rare in the larynx and can mimic a malignant process. We present the case of a 62-year-old male who required tracheotomy due to rapidly progressive stridor. Laryngoscopy showed an exophytic, occlusive tumor located in the right true vocal cord. CT showed an expansive mass measuring 2×2×1.3 cm 3 and occupying the anterior commissure, with glottic progression to the right true vocal cord. The tumor was completely resected with a CO 2 laser via a transoral approach. Histologic examination demonstrated extensive ulceration with the presence of granulation tissue. The specimen was mainly composed of spindle cells arranged in a fasciculated pattern with a myxoid background and focal hyalinization. Immunohistochemical studies revealed positivity of spindle cells to vimentin, muscle-specific actin and smooth muscle actin. The patient showed no evidence of disease 24 months after surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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