1. Extended use of systemic steroid is beneficial in preserving hearing in guinea pigs after cochlear implant.
- Author
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Rah, Yoon Chan, Lee, Min Young, Kim, Shin Hye, Kim, Doo Hee, Eastwood, Hayden, O'Leary, Stephen J., and Lee, Jun Ho
- Subjects
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ANIMAL experimentation , *AUDIOMETRY , *AUDITORY evoked response , *BRAIN stem , *COCHLEA , *COCHLEAR implants , *GUINEA pigs , *HEARING , *HEARING disorders , *HEARING levels , *HISTOLOGY , *INNER ear , *RESEARCH funding , *STATISTICS , *STEROIDS , *DATA analysis , *DEXAMETHASONE , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Conclusion:Seven-day administration of systemic steroids was more effective in preserving hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery. Objectives:To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after CI. Methods:Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. A dummy CI electrode was inserted via cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI, and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out. Results:No differences were observed in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less fibrosis and ossification in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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