1. Faecal calprotectin and gut microbiota do not predict enteropathy in very preterm infants
- Author
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Marie de Stefano, Ponny Gobalakichenane, Marie-José Butel, Florence Campeotto, Nathalie Kapel, Caroline Elie, T Hachem, Clotilde Rousseau, Mathilde Le Touzey, A Giuséppi, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Physiopathologie et pharmacotoxicologie placentaire humaine : Microbiote pré & post natal (3PHM - UMR-S 1139), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Service de microbiologie [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Service de néonatologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHI Poissy-Saint-Germain, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gestionnaire, Hal Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
faecal calprotectin ,Gut flora ,Enteral administration ,Gastroenterology ,Feces ,fluids and secretions ,0302 clinical medicine ,Pregnancy ,RNA, Ribosomal, 16S ,Enteropathy ,Prospective Studies ,030212 general & internal medicine ,biology ,Gestational age ,Regular Article ,General Medicine ,3. Good health ,Premature Birth ,Female ,necrotising enterocolitis ,Infant, Premature ,medicine.medical_specialty ,preterm neonates ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Very Preterm Birth ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,gut microbiota ,business.industry ,Infant, Newborn ,Infant ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,medicine.disease ,biology.organism_classification ,Faecal calprotectin ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Gastrointestinal Microbiome ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,enteropathy ,Pediatrics, Perinatology and Child Health ,Regular Articles & Brief Reports ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Neonatology ,Calprotectin ,business ,Leukocyte L1 Antigen Complex - Abstract
International audience; Aim: Very preterm birth is associated with a high risk of enteropathies. Diagnosis is challenging, especially in mild forms, leading to unnecessary periods of cessation of enteral feeding. This study aimed at establishing a prognosis score of enteropathy combining clinical parameters and faecal calprotectin concentration.Methods: This prospective multicentric study included preterm neonates born at a gestational age of 33 weeks or less. Stools were collected weekly until hospital discharge, and daily in case of digestive events for calprotectin measurement (ELISA and immunochromatography) and microbiota analyses (16S rRNA gene sequencing).Results: Among the 121 neonates included, 21 experienced at least one episode of enteropathy, mainly mild forms. By ELISA testing, median faecal calprotectin was 88 (8-798) µg/g faeces. No statistically significant association was found between the outset of enteropathy and maternal and neonatal characteristics, and calprotectin levels. The agreement between ELISA and immunochromatography assay was moderate (intra-class correlation coefficient 0.58, 95%CI [0.47-0.66]). Comparison of species diversity and relative bacterial abundance profiles between infants with or without enteropathy revealed no specific alterations associated with enteropathy.Conclusion: The study failed to propose a prognostic score of enteropathy, probably due the large inter- and intra-individual variability of faecal calprotectin in very preterm neonates.
- Published
- 2020