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Your search keyword '"Pei-Qing Liu"' showing total 2 results
Start Over Author "Pei-Qing Liu" Journal acta pharmacologica sinica
2 results on '"Pei-Qing Liu"'

1. SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice

Author

Ze-Yu, Li, Guo-Qing, Lu, Jing, Lu, Pan-Xia, Wang, Xiao-Lei, Zhang, Yong, Zou, and Pei-Qing, Liu

Subjects
Pharmacology, Pharmacology (medical), General Medicine
Abstract

Sirtuin3 (SIRT3), a class III histone deacetylase, is implicated in various cardiovascular diseases as a novel therapeutic target. SIRT3 has been proven to be cardioprotective in a model of Ang II-induced cardiac hypertrophy. However, a few small-molecule compounds targeting deacetylases could activate SIRT3. In this study, we generated a novel SIRT3 activator, 3-(2-bromo-4-hydroxyphenyl)-7-hydroxy-2H-chromen-2-one (SZC-6), through structural optimization of the first SIRT3 agonist C12. We demonstrated that SZC-6 directly bound to SIRT3 with K

Published
2022

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