1. The features of reserpine-induced gastric mucosal lesions
- Author
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Zhi-peng Wen, Guo-cai Lu, Shu-Wei Song, Ding-Feng Su, Xiang Zheng, Wei Liu, Qian-zhou Lü, and Xiu-Juan Ma
- Subjects
Male ,medicine.medical_specialty ,Reserpine ,Time Factors ,medicine.medical_treatment ,Blood Pressure ,Drug Administration Schedule ,Rats, Sprague-Dawley ,Internal medicine ,Rats, Inbred SHR ,medicine ,Gastric mucosa ,Animals ,Pharmacology (medical) ,Antihypertensive Agents ,Injections, Intraventricular ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,Mucosal lesions ,General Medicine ,Vagotomy ,Rats ,Sprague dawley ,Dose–response relationship ,medicine.anatomical_structure ,Blood pressure ,Endocrinology ,Gastric Mucosa ,Time course ,Hypertension ,Original Article ,business ,Injections, Intraperitoneal ,medicine.drug - Abstract
To reinvestigate the characteristics of reserpine-induced gastric mucosal lesions (GMLs). The GML-inducing effect of reserpine and the time-course of recovery from reserpine-induced GMLs were examined in Sprague-Dawley (SD) rats. The GML-inducing and blood pressure-decreasing effects of Compound Hypotensive Tablets (CHTs) were investigated in spontaneously hypertensive rats (SHRs). Intracerebroventricular (icv) injection and vagotomy were performed to verify the central vagal mechanism in reserpine-induced GMLs. Single intraperitoneal (ip) injections of reserpine (0.25, 0.5, 1, 2, 4, and 6 mg/kg) dose-dependently induced GMLs in SD rats. Both single and repeated (2 weeks) oral administrations of reserpine led to slight GMLs at doses of 24 mg/kg and 10 mg/kg, respectively. Blood pressure was significantly decreased in SHRs after 2 months of CHT administration (0.01 and 0.03 mg/kg; doses were expressed as the amount of reserpine in the CHT). CHT doses of 0.3 mg/kg induced GMLs, but 0.1 mg/kg did not. Examining the time course of recovery from GMLs, severe GMLs occurred 18 h after ip reserpine (4 mg/kg), obviously lessened at 1 week and healed spontaneously at 3 weeks. Intracerebroventricular injections of reserpine caused GMLs at much lower doses (0.08 and 0.4 mg/kg), and reserpine-induced GMLs were greatly inhibited by vagotomy, suggesting the involvement of a central vagal mechanism. Reserpine-induced GMLs were dose-dependent, and the lesions healed spontaneously within 3 weeks. Long-term treatment with CHT at doses adequate to decrease blood pressure will not induce GMLs. A central vagal mechanism was involved in reserpine-induced GMLs.
- Published
- 2010