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Your search keyword '"Renata Paprocka"' showing total 2 results
Start Over Author "Renata Paprocka" Journal acta poloniae pharmaceutica
2 results on '"Renata Paprocka"'

1. ANTIBACTERIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY OF (4,5-DIARYL-4H-1,2,4-TRIAZOL-3-YL)METHACRYLIC ACID DERIVATIVES

Author

Renata, Paprocka, Bozena, Modzelewska-Banachiewicz, Jolanta, Kutkowska, Kamil, Pawlowskp, Iwona, Piatkowska-Chmieiv, and Ewa, Jagiello-Wojtowicz

Subjects
Central Nervous System, Male, Mice, Animals, Methacrylates, Microbial Sensitivity Tests, Triazoles, Anti-Bacterial Agents
Abstract

The series of 1,2,4-triazole derivatives containing methacrylic acid moiety were synthesized in reaction of N3-substituted amidrazones with itaconic anhydride. Preliminary calculated bioavailability parameters of obtained compounds suggested good penetration via cell membranes and their good absorption after oral intake. Antimicrobial evaluation in vitio showed diverse activity of obtained triazoles mainly on Gram-positive bacterial strains. One derivative was also examined to determine the effect on the central nervous system of mice.

Published
2018

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