1. Personality traits in unaffected twins discordant for affective disorder.
- Author
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Vinberg, M., Mortensen, E. L., Kyvik, K. O., and Kessing, L. V.
- Subjects
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PERSONALITY disorders , *AFFECTIVE disorders , *LIFE change events , *MULTIVARIATE analysis , *COMORBIDITY , *TWIN psychology ,PSYCHIATRIC research - Abstract
Objective: To examine whether a high genetic liability to develop affective disorder is associated with specific personality traits. Method: A cross-sectional, high-risk, case–control study. Through nation-wide registers, healthy monozygotic (MZ) and dizygotic (DZ) twins with (high-risk twins) and without (the control group/low-risk twins) a co-twin history of affective disorder were identified. Personality traits were compared for a total of 211 high-risk and low-risk twins. Results: In univariate analyses, the high-risk twins had a higher level of neuroticism than the control twins ( P = 0.03). In multivariate analyses, a high genetic liability to affective disorder was not significantly associated with neuroticism but correlated to sex, minor psychopathology and recent life events. Conclusion: A high genetic liability to affective disorder showed an association with neuroticism, but the association interacts with other predictors of affective disorder such as female gender, minor psychopathology and recent adversity. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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