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Background: Functional dyspepsia (FD) subtypes may differ in terms of pathophysiology, but the underlying mechanisms remain poorly understood.Purpose: To explore spontaneous brain activity in two main FD subtypes, namely epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), using the amplitude of low-frequency fluctuation (ALFF).Material and Methods: Thirty-one FD patients (18 EPS and 13 PDS) and 22 matched healthy controls (HC) underwent resting-state functional MRI scanning. Spontaneous brain activity was evaluated by measuring the ALFF and then compared among the EPS, PDS, and HC groups with ANOVA test. Pearson correlation analysis was performed between the ALFF values and clinical indices.Results: Compared to healthy controls, both EPS and PDS patients had increased ALFF in the bilateral precentral/postcentral gyri, insula, and thalami. Furthermore, only the EPS patients displayed increased ALFF in the right middle and inferior frontal gyri, and only the PDS patients showed increased ALFF in the left posterior cingulate cortex (PCC). The ALFF values in the left thalamus were positively correlated with the sleep disturbance in EPS patients, and the ALFF values in the right precentral/postcentral gyri showed a positive correlation with the symptom score in PDS patients.Conclusion: EPS and PDS had similarities of higher spontaneous brain activity in the primary motor/sensory areas and homeostatic-afferent network regions, and differences in the prefrontal region and PCC, providing evidence to suggest the similarity and diversity of pathophysiology in FD subtypes. [ABSTRACT FROM AUTHOR]

Background: To diagnose pulmonary embolism (PE) in children and adults since evaluating tiny pulmonary vasculature beyond segmental level is a challenging and demanding task with thousands of images. Purpose: To evaluate the effect of computer-assisted detection (CAD) on acute PE on CTPA in children and young adults by readers with varying experience levels. Material and Methods: Six radiologists were retrospectively divided into three groups according to experience levels and assessed the CTPA studies on a per-emboli basis. All readers identified independently the PE presence, and ranked diagnostic confidence on a 5-point scale with and without CAD. Reading time, sensitivities, specificities, accuracies, positive predictive values (PPVs), and negative predictive values (NPVs) were calculated for each reading. Results: The sensitivities and NPVs differed significantly in most readers (P = 0.004, 0.001, 0.010, 0.010, and 0.012 for sensitivities and P = 0.011, 0.003, 0.016, 0.017, and 0.019 for NPVs) except for reader 6 (P = 0.148 and 0.165, respectively), and the accuracies of all readers differed significantly (all P < 0.05) in peripheral PE (beyond segmental level) detection readings with CAD versus without CAD between two reading methods. The overall time using CAD was longer than those without CAD (76.6 ± 54.4 s vs. 49.4 ± 17.7 s, P = 0.000) for all readers. Significant differences were found for confidence scores in inter-group measurements with CAD (P = 0.045) and without CAD (P < 0.001). Conclusion: At the expense of longer reading time, the use of the CAD algorithms improves sensitivities, NPVs, and the accuracies of readers in peripheral PE detection, especially for readers with a poor level of interpretation experience. [ABSTRACT FROM AUTHOR]

Background: As abdominal computed tomography (CT) radiation dose can be higher compared with other organ systems, monitoring the radiation exposure from this exam type is especially important.Purpose: To evaluate the effect of abdominal contrast-enhanced CT (CE-CT) on levels of DNA double-strand breaks (DSBs) in peripheral blood lymphocytes.Material and Methods: This study was performed in two parts: (i) an in vitro study: venous blood samples from 12 volunteers were divided into four groups. Samples in group A did not undergo radiation exposure, while groups B, C, and D received one CT scan with 1-3 times the radiation dose equivalent to abdominal CE-CT scan, respectively; and (ii) an in vivo study: blood was taken before CT and 5 min after CT in 30 patients. Lymphocytes were isolated and stained by immunofluorescence of γ-H2AX protein. DSB levels were compared by variance analysis or paired t-test. The relationship between radiation dose and γ-H2AX focus increase was analyzed using Pearson correlation analysis.Results: In the in vitro study, DSBs levels in groups B, C, and D were 49.4%, 96.6%, and 149.4% higher than those in Group A, respectively (all P < 0.001). Radiation dose in the four subgroups had a linear correlation to DSB levels ( P < 0.001). In the in vivo study, the DSB level was 43.5% higher after CT ( P < 0.001).Conclusion: Abdominal CE-CT significantly increased DSB levels in both in vitro and in vivo experiments. A positive linear correlation of CT radiation dose with intracellular DSBs levels was observed in the in vitro study. [ABSTRACT FROM AUTHOR]

Background: The smallest diagnostically appropriate amount of contrast medium should be used in coronary computed tomography angiography (CCTA).Purpose: To investigate the feasibility of prospectively ECG-triggered high-pitch CCTA using 30 mL of 270 mg I/mL contrast material, 80 kVp, and iterative reconstruction (IR).Material and Methods: Eighty-two consecutive patients underwent CCTA with a prospectively ECG-triggered high-pitch protocol. Forty-three patients were examined at 100 kVp with filtered back projection after 60 mL of 370 mg I/mL contrast material was administered. Another 39 patients were examined at 80 kVp with IR after 30 mL of 270 mg I/mL contrast material was administered. Subjective and objective image quality was evaluated for each patient. Radiation doses were estimated and compared.Results: Mean attenuation, noise and signal-to-noise ratio in 80 kVp group were significantly lower than in 100 kVp group (all P < 0.05), while there was no significant difference in contrast-to-noise ratio (CNR), although a trend towards a lower CNR in 80 kVp group was observed (P = 0.099). The subjective image quality between the two groups was not significantly different (P = 0.905). The effective dose and iodine load in 80 kVp group were reduced by 54% and 64%, respectively, when compared with 100 kVp group.Conclusion: Prospectively ECG-triggered high-pitch CCTA at 80 kVp with 30 mL of 270 mg I/mL contrast material and IR is feasible for patients with BMI less than 25 kg/m(2) and reduces radiation dose and iodine load when compared with the standard CCTA protocol. [ABSTRACT FROM AUTHOR]