1. Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study
- Author
-
Tilmann Graeter, Julian Schmidberger, Eric Delabrousse, Eleonore Brumpt, Wolfgang Kratzer, Haihua Bao, Rong Shi, Yi Jiang, Weixia Li, and Wenya Liu
- Subjects
Male ,Pathology ,Proliferation ,Alveolar echinococcosis ,biliary involvement ,Disease ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,METASTASES FORMATION ,PROPOSAL ,vascular ,Germany ,MRI FINDINGS ,Child ,Aged, 80 and over ,Fuchsbandwurm ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,biology ,General Medicine ,Middle Aged ,Classification ,Magnetic Resonance Imaging ,Liver ,Female ,France ,Infiltration (medical) ,Cohort study ,Adult ,medicine.medical_specialty ,China ,Adolescent ,BILIARY COMPLICATIONS ,MULTILOCULARIS ,Echinococcus multilocularis ,03 medical and health sciences ,extrahepatic manifestation ,Young Adult ,Magnetic resonance imaging ,Echinococcosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,Aged ,business.industry ,Kernspintomografie ,biology.organism_classification ,medicine.disease ,Kodama classification ,Vorschlag ,Bile Ducts ,Eingruppierung ,business ,DDC 610 / Medicine & health ,030217 neurology & neurosurgery - Abstract
Background The main endemic areas of alveolar echinococcosis (AE) are in central Europe and western China. The infiltration of intrahepatic vascular and bile ducts as well as extrahepatic disease can lead to complications and may increase morbidity in AE. Purpose To evaluate the vascular/biliary involvement of hepatic alveolar echinococcosis (HAE) and distant extrahepatic disease at each of four locations in Germany, France, and China. Material and Methods Contrast-enhanced abdominal magnetic resonance imaging (MRI) scans of patients with HAE, 200 in total, were evaluated by five examiners. AE liver lesions were classified according to Kodama’s classification. Furthermore, distant extrahepatic manifestations were documented with additionally performed imaging modalities. Vascular/biliary involvement of hepatic manifestations as well as the presence of extrahepatic manifestations were correlated with the respective Kodama type of the liver lesion. Results Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe (12/100 vs. 3/100; Fisher’s exact test: P=0.0286). A significant relationship exists between presence of distant extrahepatic disease manifestation and size of the AE liver lesion (132.53 ± 48.65 vs. 92.49 ± 50.06; P = 0.0030). Vascular/biliary involvement is significantly more frequent in China than in Europe (86/100 vs. 65/100; χ2 = 11.92; P = 0.0006). Vascular/biliary involvement depends on lesion size (111.10 ± 47.44 vs. 47.36 ± 24.36; P, publishedVersion
- Published
- 2020