1. Control of transcription in Schistosoma mansoni: chromatin remodeling and other regulatory elements
- Author
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Renata M. Santos, Daniel Rodrigues Furtado, Franklin David Rumjanek, Francisco Meirelles Bastos de Oliveira, Marcelo Rosado Fantappié, José João Mansure, and Isabel Caetano de Abreu da Silva
- Subjects
Genetics ,biology ,Veterinary (miscellaneous) ,Schistosomiasis ,Schistosoma mansoni ,biology.organism_classification ,medicine.disease ,Chromatin Assembly and Disassembly ,Chromatin remodeling ,Chromatin ,Infectious Diseases ,Gene Expression Regulation ,Transcription (biology) ,Insect Science ,parasitic diseases ,medicine ,Parasite hosting ,Animals ,Parasitology ,Regulatory Elements, Transcriptional ,Transcription factor - Abstract
The platyhelminth parasite Schistosoma mansoni, the causative agent of schistosomiasis, is a dioecious parasite with a complex life cycle that includes two different hosts and two free-living stages. Yet very little is known about the biochemical details connected to these different transitions. In the present work, results will be presented showing the most recent results in S. mansoni regarding the characterization of transcription factors and coactivators that act directly on the transcriptional machinery and those that are involved with chromatin remodeling. It is hoped that the information gathered here may contribute towards the understanding of crucial events in the parasite life cycle. Likewise, the development of new drugs that could interfere with oogenesis and sexual maturation may eventually profit from the information contained herein. more...
- Published
- 2007