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1. Insulin Delivery: Erythrocyte‐Membrane‐Camouflaged Nanoplatform for Intravenous Glucose‐Responsive Insulin Delivery (Adv. Funct. Mater. 41/2018).

Author

Fu, Yu, Liu, Wei, Wang, Lu‐yao, Zhu, Bi‐yue, Qu, Meng‐ke, Yang, Liu‐qing, Sun, Xun, Gong, Tao, Zhang, Zhi‐rong, Lin, Qing, and Zhang, Ling

Subjects
*INSULIN therapy, *DRUG delivery systems, *INTRAVENOUS therapy, *GLUCOSE metabolism, *ENZYMATIC analysis, *ERYTHROCYTES
Abstract

In article number 1802250 Qing Lin, Ling Zhang, and co‐workers report an artificial "closed‐loop" structure for intravenous glucose‐responsive insulin delivery. An acid‐sensitive matrix forms the "inner core" and RBCm‐derived coating the "outer shell". Under hyperglycemic condition, the glucose internalized by the anchored glucose transporters is enzymatically converted into gluconic acid and subsequently triggers acid degradation of the "inner core" to secrete insulin. [ABSTRACT FROM AUTHOR]

Published
2018
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