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3. Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery

Author

Jingwei Xue, Qiong Sun, Qineng Ping, Nan Li, Wenyuan Li, Ran Mo, and Can Zhang

Subjects
Cell Survival, Transplantation, Heterologous, Heterologous, Antineoplastic Agents, Mitochondrion, Pharmacology, Mice, Cell Line, Tumor, Neoplasms, Animals, Humans, Tissue Distribution, General Materials Science, Sirolimus, Oligopeptide, Liposome, Chemistry, Mechanical Engineering, Hydrogen-Ion Concentration, Anticancer drug, Mitochondria, Transplantation, Mechanics of Materials, Cell culture, Liposomes, Drug delivery, Oligopeptides
Abstract

Zwitterionic oligopeptide liposomes (HHG2C(18)-L) containing a smart lipid (1,5-dioctadecyl-L-glutamyl 2-histidyl-hexahydrobenzoic acid, HHG2C(18)) are developed to overcome the barriers faced by anticancer drugs on the route from the site of injection into the body to the final antitumor target within transport steps with multiple physiological and biological barriers. HHG2C(18)-L show the multistage pH-responsive to the tumor cell (the mitochondria in this case). Their multistage pH response leads to more effective entry of the tumor cell, improved escape from the endolysosomes, and accumulation at the mitochondria (see picture).

Published
2012
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