Search

The combination of herb medicine is alternative option in hypertension because it has more potential for treatment with complications like hyperlipida. Plant which can be used for anti-hypertension therapy is combination of celery herb (Apium graveolens) and bay leaf ethanol extract (Syzygium polyanthum). This research aims to determine the activity of a combination of celery herb ethanol extract (CHEE) and bay leaf ethanol extract (BLEE) and find out how much the decrease of blood pressure on the combination of both toward hypertension with high fat Wistar mice. The design of this research used an experimental design with pre-post control group design. Hypertensive mice are induced with high fat feed and orally with sodium chloride 8%, then the mice are supplied with combinations extract with the dose of 1.125 ; 6.25 ; 2.25 ; 12.5 and 4.5 ; 25 mg/kg, hydrochlorotiazide 2.25 mg/kg, Simvastatin 0.9 mg/kg, CHEE 4.5 mg/kg, BLEE 25 mg/kg and CMC-Na 0.5%. Research result shows that the combination can decrease systole blood pressure in the 22nd day. The extract combination has anti-hypertension effect (it is able to decrease systole blood pressure ≥ 20 mmHg) and it is not significantly different with normal group (p

Celery (Apium graveolensL.) and Bay (Syzygium polyanthumWight) contain active compound of flavonoid which can obstruct reabsorbsion of Na and water until increase diuretic effect. This research aims to know diuretic effect combinations from celery herb and bay leaf ethanol extract 70% toward Wistar Male Mice using Lipschitz test. The research design is experimental withposttest only control group designby deviding the mice into normal group, hydrochlorothiazide group 25 mg/kg, control CMC-Na 0.5%, and combinations of celery herb (CHEE) and bay leaf ethanol extract(BLEE) treatment group. Those were made in 3 variances combinations doses which are; 1.125 mg/kg:6.25 mg/kg (combination-1), 2.25 mg/kg:12.5 mg/kg (combination-2), and 4.5 mg/kg:25 mg/kg (combination-3) and also 2 single doses of CHEE 4.5 mg/kg and BLEE 25 mg/kg. Diuretic effect is determined by a diuretic index and Lipschitz value. Urine volume is analyzed with ANOVA and continued analyzing with non parametric Kruskal-Wallis and Mann Whitney. The results of diuretic effect combinations from CHEE and BLEE showed that the three combinations have diuretic effect with value index in series from the smallest dose combinations are; 1.83, 1.86, 2.09 at 5 hours and 1.73, 1.75, 2.02 at 24 hours. Lipschitz values are 0.78, 0.79, 0.89 at 5 hours observation and 0.79, 0.79, 0.913 at 24 hours. Diuretic energy are ; 69.84%, 72.48%, 94.12% at 5 hours and 65.79%, 67.79%, 93.15% at 24 hours. Based on the test results of diuretic effects, combinations of CHEE and BLEE have diuretic effect and combination-3 which is the closest to hydrochlorothiazide.

Celery herb contains flavonoid which can hamper cholesterol synthesis through inhibitor HMG-CoA reductase. Bay leaf has a working mechanism that stimulates bile fluid secretion and stimulates blood circulation. This research aims to know the activity combinations of bay leaf ethanol extract (BLEE) and celery herb ethanol extract (CHEE) and to know which dose mostly can decrease lipid profile levels. The design of this research uses experimental withpre-post control group design.The mice are rendered with NaCl 8% solution and High Fat Feed. The mice are divided into 9 groups, in each group there are 5 mice which are normal group, control group, HCT group, Simvastatin group, and CHEE 4.50 mg/kgBW, BLEE 25.00 mg/kgBW, combination 1, combination 2, and combination 3. Data analysis is conducted with Normality test,One Way ANOVAtest,Kruskal-Wallis,Mann-Whitney. Based on the research after they are induced with NaCl 8% solvent and given high-fat feed, the extract can increase total cholesterol levels, triglycerides, LDL, and also significantly decrease HDL (p