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As a promising prevention and therapeutic intervention in Alzheimer’s disease, natural food dyes curcumin could obviously inhibit the generation of Aβ, but the mechanism is not fully defined. This study aims to investigate the effects of curcumin on the amyloidogenic pathway of APP in vitro. Plasmids APPswe and BACE1-mychis were transiently co-transfected into SH-SY5Y and HEK293 cells. Then, they were treated with curcumin at 0, 1.25, 5, 20 μmol/L for 24 h, or with curcumin at 5μmol/L for 0, 12, 24 and 48 h for the time course assay. Our findings showed that curcumin could inhibit the expression of the APP at mRNA level; the expression of the BACE1 and C99 at mRNA and protein levels, furthermore it could inhibit the generation of Aβ40/42, and those changes were dose-time dependent (p

In the 1960s, rapid economic growth of Japan resulted in urban problems such as public hazard, environmental pollution and destruction of historic streetscape etc. To rescue increasingly worsening living environment, various citizen endeavors have been carried out. The reflection of modern urban planning was called "Machi-zukuri". After tens of years of evolution, it has become the representative of the citizens and the citizen groups participating in urban planning, design and government affairs. Landscape "Machi-zukuri" is one of its important types. Through the case analysis of Chiba Townscape Citizen Festival, this paper discusses the successful experience of Japan in improving regional landscape architecture which is worth our reference.

Hydrogen-producing zymogenous bacteria YUAN-3 (Ethanoligenens harbinense) is used as the study object, on which the intermittent hydrogen production test is applied to examine the influence of Magnesium ions concentration on the growth and gas generation of YUAN-3. Research results show that when Magnesium ions concentration is 0.3g/L, volatile acid reaches the maximum level; when Magnesium ions concentration is maintained at 0.3g/L, the unit volume production of hydrogen reaches at 256mlH2/L，culture medium is applicable for hydrogen generation of YUAN-3.

Hydrogen-producing zymogenous bacteria YUAN-3 (Ethanoligenens harbinense) is used as the study object, on which the intermittent hydrogen production test is applied to examine the influence of Na-ion concentration on the growth and gas generation of YUAN-3. Research results show that when Na ion concentration is 1.5g/L, cell concentration reaches the maximum level 0.892g/L; when Na-ion concentration is maintained at 2.0~3.0g/L, culture medium is applicable for hydrogen generation of YUAN-3.

Continuous dark fermentative hydrogen production technology is suitable for commercial application. This review summarized several main basic factors influencing the operation of the reactor, followed by some suggestions and outlooks. The factors included temperature, pH, HRT and COD were briefly introduced and discussed. This review demonstrated that the optimal value of a given factor under different conditions was great different. This indicates that reactor operation is affected by many factors and sensitive to environmental change. To make the technology more feasible into practice, deeply understanding about the characteristics and rules of the operation is necessary. Thus more researches in this respect are recommended.