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Based on the thermo elasticity theory, the stress of femur prosthesis system was analyzed using finite element method. An evaluation for the selection of prosthetic material was presented after discussing the thermo physical property of material which had an effect on the stress of femur prosthesis system. The results indicate that the interface failure is the primary failure form of the femoral prosthesis system and the interface failure is accelerated for the reason of the thermal effect. So the prosthesis with low coefficient of thermal expansion should be selected which can moderate the interface failure in the certain degree.