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Inflammation‐responsive hydrogels loaded with therapeutic factors are effective biomaterials for bone tissue engineering and regenerative medicine. In this study, a matrix metalloproteinase (MMP)‐responsive injectable hydrogel is constructed by integrating an MMP‐cleavable peptide (pp) into a covalent tetra‐armed poly‐(ethylene glycol) (PEG) network for precise drug release upon inflammation stimulation. To establish a pro‐regenerative environment, phosphatidylserine (PS) is encapsulated into a scaffold to form the PEG‐pp‐PS network, which could be triggered by MMP to release a large amount of PS during the early stage of inflammation and retain drug release persistently until the later stage of bone repair. The hydrogel is found to be mechanically and biologically adaptable to the complex bone defect area. In vivo and in vitro studies further demonstrated the ability of PEG‐pp‐PS to transform macrophages into the anti‐inflammatory M2 phenotype and promote osteogenic differentiation, thus, resulting in new bone regeneration. Therefore, this study provides a facile, safe, and promising cell‐free strategy on simultaneous immunoregulation and osteoinduction in bone engineering. [ABSTRACT FROM AUTHOR]

Traditional lithium‐ion batteries cannot meet the ever‐increasing energy demands due to the unsatisfied graphite anode with sluggish electrochemical kinetics. Recently, the perovskite material family as anode attracts growing attention due to their advantages on specific capacity, rate capability, lifetime, and safety. Herein, a double perovskite La2MnNiO6 synthesized by solid‐state reaction method as a high‐performance anode material for LIBs is reported. La2MnNiO6 with an average operating potential of <0.8 V versus Li+/Li exhibits a good rate capability. Besides, the Li|La2MnNiO6 cells perform long cycle life without decay after 1000 cycles at 1C and a high cycling retention of 93% is observed after 3000 cycles at 6C. It reveals that this material maintains stable perovskite structure with cycling. Theoretical calculations further demonstrate the high electronic conductivity, low diffusion energy barrier, and structural stability of the lithiated La2MnNiO6. This study highlights the double perovskite type material as a promising anode for next‐generation batteries. [ABSTRACT FROM AUTHOR]