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Your search keyword '"Martínez‐Lara, Fernando"' showing total 3 results
Start Over Author "Martínez‐Lara, Fernando" Journal advanced synthesis & catalysis
3 results on '"Martínez‐Lara, Fernando"'

3. Gold‐Catalyzed Reactions of 2‐Alkynyl‐1‐indolyl‐1,2‐diols with Thiols: Stereoselective Synthesis of (Z)‐α‐Indol‐3‐yl α‐(2‐Thioalkenyl) Ketones.

Author

Martínez‐Lara, Fernando, Suárez, Anisley, Velasco, Noelia, Suárez‐Pantiga, Samuel, and Sanz, Roberto

Subjects
*GLYCOLS, *KETONES, *ACYLOINS, *THIOLS, *ETHYLENE glycol, *HOMOGENEOUS catalysis, *SULFUR
Abstract

Propargylic glycols, 2‐alkynyl‐1‐(indol‐3‐yl)‐1,2‐diols, react with thiols undergoing a complex but selective gold‐catalyzed transformation that gives rise to α‐indol‐3‐yl α‐((Z)‐2‐thioalkenyl) ketones. The sequence is triggered by the regioselective thiolation of indolyl diols followed by an attack of the sulfur instead of the indole over the activated alkyne. The final compounds are obtained in remarkably high yields and arise from simple starting materials such as indolyl acyloins, ethynyl magnesium bromide and thiols. [ABSTRACT FROM AUTHOR]

Published
2022
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