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To commemorate 100 years since the birth of Professor Duzheng YE, this paper reviews the contribution of Ye and his research team to the development from climate to global change science in the past 30 or so years, including: (1) the role of climate change in global change; (2) the critical time scales and predictability of global change; (3) the sensitive regions of global change-transitional zones of climate and ecosystems; and (4) orderly human activities and adaptation to global change, with a focus on the development of a proactive strategy for adaptation to such change. [ABSTRACT FROM AUTHOR]