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Your search keyword '"G. Ceresoli-Borroni"' showing total 2 results
Start Over Author "G. Ceresoli-Borroni" Journal advances in experimental medicine and biology
2 results on '"G. Ceresoli-Borroni"'

1. Modulation and function of kynurenic acid in the immature rat brain

Author

R, Schwarcz, G, Ceresoli-Borroni, H Q, Wu, A, Rassoulpour, B, Poeggeler, P S, Hodgkins, and P, Guidetti

Subjects
Male, Neurons, Aging, Alanine, Dextroamphetamine, N-Methylaspartate, Microdialysis, Brain, Kynurenic Acid, Mixed Function Oxygenases, Rats, Rats, Sprague-Dawley, Glucose, Kynurenine 3-Monooxygenase, 2-Amino-5-phosphonovalerate, Animals, Enzyme Inhibitors, Pyruvates, Excitatory Amino Acid Antagonists
Abstract

Using in vivo and in vitro paradigms, the regulation and function of the brain metabolite kynurenic acid (KYNA) was examined in rats on postnatal days (PND) 7 and 14. As shown previously in adult rats, glucose removal and d-amphetamine (d-Amph) administration caused decreases in KYNA formation, while exposure to pyruvate up-regulated KYNA synthesis. The effect of glucose deprivation was substantially blunted in immature animals. In PND 14 rats, d-Amph pre-treatment exacerbated the excitotoxic effects of an intrastriatal N-methyl-D-aspartate (NMDA) injection. This potentiation was prevented by m-nitrobenzoylalanine, a kynurenine 3-hydroxylase inhibitor that also antagonized the KYNA reduction caused by d-Amph. These and additional experiments with the competitive NMDA receptor antagonist CGP 40116 indicate the existence of a functionally significant, novel high-affinity receptor for KYNA in the brain.

Published
2000

2. Modulation and function of kynurenic acid in the immature rat brain.

Author

Schwarcz R, Ceresoli-Borroni G, Wu HQ, Rassoulpour A, Poeggeler B, Hodgkins PS, and Guidetti P

Subjects
2-Amino-5-phosphonovalerate analogs & derivatives, 2-Amino-5-phosphonovalerate pharmacology, Aging metabolism, Alanine analogs & derivatives, Alanine pharmacology, Animals, Brain drug effects, Brain growth & development, Dextroamphetamine pharmacology, Enzyme Inhibitors pharmacology, Excitatory Amino Acid Antagonists pharmacology, Glucose metabolism, Kynurenine 3-Monooxygenase, Male, Microdialysis, Mixed Function Oxygenases antagonists & inhibitors, N-Methylaspartate pharmacology, Neurons drug effects, Neurons physiology, Pyruvates pharmacology, Rats, Rats, Sprague-Dawley, Brain physiology, Kynurenic Acid metabolism
Abstract

Using in vivo and in vitro paradigms, the regulation and function of the brain metabolite kynurenic acid (KYNA) was examined in rats on postnatal days (PND) 7 and 14. As shown previously in adult rats, glucose removal and d-amphetamine (d-Amph) administration caused decreases in KYNA formation, while exposure to pyruvate up-regulated KYNA synthesis. The effect of glucose deprivation was substantially blunted in immature animals. In PND 14 rats, d-Amph pre-treatment exacerbated the excitotoxic effects of an intrastriatal N-methyl-D-aspartate (NMDA) injection. This potentiation was prevented by m-nitrobenzoylalanine, a kynurenine 3-hydroxylase inhibitor that also antagonized the KYNA reduction caused by d-Amph. These and additional experiments with the competitive NMDA receptor antagonist CGP 40116 indicate the existence of a functionally significant, novel high-affinity receptor for KYNA in the brain.

Published
1999
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