1. Effect of single oral doses of prednisone and deflazacort on human lymphocyte distribution and functions. Analysis with monoclonal antibodies.
- Author
-
Scudeletti M, Pende D, Barabino A, Imbimbo B, Grifoni V, and Indiveri F
- Subjects
- Adult, Cells, Cultured, DNA biosynthesis, Histocompatibility Antigens Class II analysis, Humans, Lymphocyte Activation drug effects, Lymphocyte Culture Test, Mixed, Prednisone administration & dosage, Pregnenediones administration & dosage, Rosette Formation, T-Lymphocytes immunology, T-Lymphocytes metabolism, T-Lymphocytes physiology, Thymidine metabolism, Antibodies, Monoclonal, Prednisone pharmacology, Pregnenediones pharmacology, T-Lymphocytes drug effects
- Abstract
Two corticosteroids, prednisone and deflazacort, have been compared with respect to their capacity of inducing redistribution of T lymphocyte subsets, modification of expression of Ia antigens by PHA primed T cells, and inhibition of blastogenesis of T cells in autologous mixed lymphocyte reactions. Both corticosteroids were able to induce T lymphocytes depletion, increase of suppressor T cells, inhibit Ia expression upon mitogenic activation of T lymphocytes, and inhibit autologous MLRs either when non T cells or when PHA T lymphocytes were used as stimulators. We conclude that deflazacort may constitute a better glucocorticoid than prednisone for correcting the imbalance among T cells subsets, the helper T cells activity and the processes of cell-to-cell cooperation in immune diseases.
- Published
- 1984