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20 results on '"de Abreu RA"'

1. Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia.

Author

Brouwer C, Keizer-Garritsen JJ, Lambooy LH, Ament K, Ter Riet PG, De Abreu RA, Bökkerink JP, Van Wering ER, Van Der Does-Van Den Berg A, Veerman AJ, and Trijbels JP

Subjects
Alleles, Antimetabolites, Antineoplastic therapeutic use, Child, Female, Genetic Testing, Genotype, Humans, Male, Mercaptopurine therapeutic use, Methotrexate therapeutic use, Mutation, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Methyltransferases genetics, Methyltransferases metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma enzymology
Published
2000
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2. 6-mercaptopurine: efficacy and bone marrow toxicity in childhood acute lymphoblastic leukemia. Association with low (thio)purine enzyme activity.

Author

De Abreu RA, Lambooy LH, Ahment K, Brouwer C, Keizer-Garritsen JJ, Bokkerink JP, and Trijbels FJ

Subjects
Antimetabolites, Antineoplastic therapeutic use, Child, Humans, Mercaptopurine therapeutic use, Methyltransferases genetics, Purines metabolism, Antimetabolites, Antineoplastic adverse effects, Bone Marrow drug effects, Mercaptopurine adverse effects, Methyltransferases metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Published
2000
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3. Thiopurine treatment in childhood leukemia. Metabolic aspects and sensitivity.

Author

De Abreu RA, Bokkerink JP, Keuzenkamp-Jansen CW, Stet EH, and Trijbels JF

Subjects
Antimetabolites, Antineoplastic pharmacokinetics, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Chromosomes, Human, Pair 6, Humans, Leukemia metabolism, Mercaptopurine administration & dosage, Mercaptopurine pharmacokinetics, Methotrexate administration & dosage, Methyltransferases deficiency, Methyltransferases genetics, Polymorphism, Genetic, Thioguanine pharmacokinetics, Antimetabolites, Antineoplastic therapeutic use, Leukemia drug therapy, Mercaptopurine therapeutic use, Methyltransferases metabolism, Thioguanine therapeutic use
Published
1998
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4. Clinical and biochemical aspects of dihydropyrimidinase deficiency.

Author

Van Gennip AH, De Abreu RA, Vreken P, and Van Kuilenburg AB

Subjects
Biomarkers urine, Humans, Purine-Pyrimidine Metabolism, Inborn Errors diagnosis, Purine-Pyrimidine Metabolism, Inborn Errors urine, Reference Values, Thymine analogs & derivatives, Thymine urine, Uracil analogs & derivatives, Uracil urine, Amidohydrolases deficiency, Purine-Pyrimidine Metabolism, Inborn Errors metabolism
Published
1998
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5. Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity.

Author

Van Kuilenburg AB, Vreken P, Beex LV, Meinsma R, Van Lenthe H, De Abreu RA, and Van Gennip AH

Subjects
Alternative Splicing, Base Sequence, Chemotherapy, Adjuvant, Dihydrouracil Dehydrogenase (NADP), Exons, Female, Fluorouracil administration & dosage, Humans, Introns, Leukocytes, Mononuclear enzymology, Middle Aged, Oxidoreductases biosynthesis, Oxidoreductases blood, Polymerase Chain Reaction, RNA, Messenger biosynthesis, Tamoxifen administration & dosage, Transcription, Genetic, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Fluorouracil adverse effects, Heterozygote, Oxidoreductases genetics, Point Mutation
Published
1998
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6. Azathioprine treatment and thiopurine metabolism in rheumatic diseases. Introduction and first results of investigation.

Author

Stolk JN, Boerbooms AM, De Abreu RA, and van de Putte LB

Subjects
5'-Nucleotidase blood, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid immunology, Cross-Sectional Studies, Humans, Hypoxanthine Phosphoribosyltransferase blood, Immunoglobulin M blood, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic immunology, Methyltransferases blood, Reference Values, Rheumatoid Factor blood, Antirheumatic Agents pharmacokinetics, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Azathioprine pharmacokinetics, Azathioprine therapeutic use, Lupus Erythematosus, Systemic drug therapy, Mercaptopurine blood
Published
1998
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7. Intracellular pharmacology and biochemistry of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia.

Author

Keuzenkamp-Jansen CW, Bökkerink JP, Trijbels JM, vd Heijden MA, and De Abreu RA

Subjects
Administration, Oral, Antineoplastic Combined Chemotherapy Protocols metabolism, Child, Erythrocytes drug effects, Erythrocytes metabolism, Humans, Infusions, Intravenous, Leucovorin administration & dosage, Leukocytes, Mononuclear drug effects, Leukocytes, Mononuclear metabolism, Mercaptopurine administration & dosage, Mercaptopurine pharmacology, Methotrexate administration & dosage, Methotrexate pharmacology, Purines blood, Pyrimidines blood, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Mercaptopurine metabolism, Methotrexate metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Published
1994
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8. Nucleotide metabolism: mode of action of thiopurines in leukemia.

Author

De Abreu RA

Subjects
Animals, Antimetabolites, Antineoplastic metabolism, Antimetabolites, Antineoplastic pharmacology, Cell Survival drug effects, DNA, Neoplasm metabolism, Humans, Leukemia metabolism, Mercaptopurine metabolism, Mercaptopurine pharmacology, Mercaptopurine therapeutic use, Purines metabolism, Purines pharmacology, RNA, Neoplasm metabolism, Sulfhydryl Compounds metabolism, Sulfhydryl Compounds pharmacology, Sulfhydryl Compounds therapeutic use, Antimetabolites, Antineoplastic therapeutic use, Leukemia drug therapy, Nucleotides metabolism, Purines therapeutic use
Published
1994
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9. Influence of purines on endothelial high energy phosphates.

Author

Griesmacher A, De Abreu RA, and Müller MM

Subjects
Adenosine Diphosphate metabolism, Adenosine Triphosphate metabolism, Carbon Radioisotopes, Cells, Cultured, Endothelium, Vascular drug effects, Guanosine Diphosphate metabolism, Guanosine Triphosphate metabolism, Humans, Radioisotope Dilution Technique, Umbilical Veins, Endothelium, Vascular metabolism, Energy Metabolism drug effects, Purines metabolism, Purines pharmacology, Ribonucleotides pharmacology
Abstract

It was demonstrated that extracellularly available adenosine, which is reported to protect the endothelium during ischaemia and reperfusion [8], is predominantly uptaken and salvaged by HUVECs, thereby enriching the adenine phosphate pool. In this way adenosine could contribute to a regeneration of metabolically disturbed cells via increasing the intracellular ATP. In contrast, all other purines offered can hardly be used by HUVECs to increase the pool of energy rich phosphates.

Published
1994
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10. 6-Mercaptopurine metabolism in two leukemic cell lines.

Author

Stet EH, De Abreu RA, Janssen YP, Bökkerink JP, and Trijbels JM

Subjects
Biotransformation, Carbon Radioisotopes, Cell Division drug effects, Cell Line, Cell Survival drug effects, Humans, Inosine Monophosphate metabolism, Leukemia-Lymphoma, Adult T-Cell, Mercaptopurine pharmacology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, IMP Dehydrogenase metabolism, Mercaptopurine metabolism, Mycophenolic Acid pharmacology
Published
1991
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11. Synergistic interaction of methotrexate and 6-mercaptopurine in human derived malignant T-ALL and CALLA+ cell lines.

Author

De Abreu RA, van Strien F, Lambooy LH, and Bökkerink JP

Subjects
Carbon Radioisotopes, Cell Division drug effects, Cell Line, Drug Screening Assays, Antitumor, Drug Synergism, Glycine metabolism, Humans, Kinetics, Leukemia-Lymphoma, Adult T-Cell, Phosphates metabolism, Phosphorus Radioisotopes, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Purines metabolism, Tetrahydrofolate Dehydrogenase metabolism, Thymidine Monophosphate metabolism, Mercaptopurine pharmacology, Methotrexate pharmacology
Published
1991
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14. Inhibition of 3H-thymidine incorporation by adenosine and deoxyadenosine in human peripheral lymphocytes and malignant lymphoid cell lines.

Author

van der Krann PM, van Zandvoort PM, De Abreu RA, Bakkeren JA, van Laarhoven JP, and de Bruijn CH

Subjects
Adenosine Deaminase Inhibitors, Cell Line, Cells, Cultured, Coformycin analogs & derivatives, Coformycin pharmacology, Humans, Lymphocyte Activation drug effects, Lymphocytes cytology, Mitogens, Pentostatin, Thymidine metabolism, Adenosine toxicity, DNA biosynthesis, Deoxyadenosines toxicity, Lymphocytes drug effects
Published
1986
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15. Increased availability of phosphoribosyl pyrophosphate as the basis for enhanced 6-mercaptopurine incorporation by methotrexate, in cultured human lymphoblasts.

Author

Bökkerink JP, de Abreu RA, van Laarhoven JP, Bakker MA, Hulscher TW, Schretlen ED, and de Bruijn CH

Subjects
B-Lymphocytes drug effects, B-Lymphocytes metabolism, Cell Line, Humans, Purines biosynthesis, T-Lymphocytes drug effects, T-Lymphocytes metabolism, Mercaptopurine metabolism, Methotrexate pharmacology, Pentosephosphates metabolism, Phosphoribosyl Pyrophosphate metabolism
Published
1986
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16. Dihydrothymine dehydrogenase deficiency in a family, leading to elevated levels of uracil and thymine.

Author

De Abreu RA, Bakkeren JA, Braakhekke J, Gabreels FJ, Maas JM, and Sengers RC

Subjects
Child, Chromatography, Gas, Dihydrouracil Dehydrogenase (NAD+), Female, Fibroblasts metabolism, Humans, Male, Purine-Pyrimidine Metabolism, Inborn Errors diagnosis, Reference Values, Oxidoreductases deficiency, Oxidoreductases Acting on CH-CH Group Donors, Purine-Pyrimidine Metabolism, Inborn Errors genetics, Thymine metabolism, Uracil metabolism
Published
1986
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18. Synergy of methotrexate and 6-mercaptopurine on cell growth and clonogenicity of cultured human T-lymphoblasts.

Author

De Abreu RA, Bökkerink JP, Bakker MA, Hulscher TW, de Vaan GA, de Bruijn CH, and Schretlen ED

Subjects
Cell Line, Cell Survival drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Synergism, Humans, T-Lymphocytes cytology, T-Lymphocytes drug effects, Cell Cycle drug effects, Mercaptopurine administration & dosage, Methotrexate administration & dosage
Published
1986
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20. Influence of methotrexate on purine and pyrimidine pools and on cell phase distribution of cultured human lymphoblasts.

Author

De Abreu RA, Bökkerink JP, Bakker MA, Hulscher TW, van Baal JM, de Bruijn CH, and Schretlen ED

Subjects
Cell Line, Cell Survival drug effects, Cells, Cultured, DNA analysis, Deoxyribonucleotides metabolism, Humans, Ribonucleotides metabolism, Uridine Monophosphate metabolism, Cell Cycle drug effects, Methotrexate pharmacology, Purines metabolism, Pyrimidines metabolism
Published
1986
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