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The aviation industry has a global economic impact of $2.7 trillion (including direct, indirect, induced, and tourism catalytic effects) and contributes 3.6 percent of global GDP. Weather is one of the most essential elements impacting how an aircraft runs and how safely it can fly. The correlation coefficient is the most significant index explaining the relationship between variables and can result in teleconnection patterns of climate indices. El Nino-Southern Oscillation (ENSO) and India Ocean Dipole (IOD) were used in this study based on the ERA5 reanalysis dataset for 30 years (1991–2020). Myanmar's Yangon International Airport has recorded more than 119874 times of observation data from 2009 to 2019. The mean percentage of occurrences of weather elements is calculated for each month and each season. Analysis of flight delay and accident data was obtained statistically from the Aviation Safety Network (ASN). According to the monthly delay index, July, August, and March are the maximum delay index months, and the correlation value between aircraft movement and delays is maximum in July and August and minimum in January and February. After examining numerous characteristics of Yangon International Airport, we identified which elements had a big impact on operations through vital interviews with operators, the accident case study section, and climatology analysis. As a result, we identified two meteorological occurrences: thunderstorm rain (TSRA) and fog (FG) are of high frequency and TSRA poses a larger risk than FG for aviation operation. The maximum frequency (%) of thunderstorm occurrences was 22% in July and the minimum was 1% in January. Annual frequency analysis revealed that TSRA days are becoming more common year after year as a result of global climate change. According to a spatial gridded analysis by ERA5 reanalysis data (1991–2020), the annual convective available potential energy (CAPE) values over local airport regions, the Bay of Bengal (BOB), the western equatorial Pacific, and the South China Sea show a positive correlation with convective rainfall. In contrast, negative convective inhibition (CIN) anomalies have been observed over the same areas as above, except for the western part of BOB along the Indian Coast. The primary innovation is that we look at the effects of thunderstorms on airport operations before determining their link with ENSO and the IOD individually and then combining them during their full phases. This raises a new question and a new possibility for viewing climatology from a new perspective. [ABSTRACT FROM AUTHOR]