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The performance research based on numerical and experimental studies on ultra-high performance concrete (UHPC) generally considers it as an isotropic material, which is obviously different from what it really is in practical engineering. A database of UHPC compressive strength was investigated, having the same UHPC mix proportion as the field blast experiment, to show how the strength of UHPC varies in compression. It is found that Weibull distribution is the best fit of its probability model. A combination of Monte-Carlo and Finite Element method is used, adopting the available UHPC compressive strength, to reproduce the field blast test on UHPC columns. Both the non-spatial and spatial variability of material properties of the UHPC columns are under consideration to conduct the UHPC column strength prediction under blast loads. The residual loading capacity, damage index and failure mode of UHPC columns with different sizes damaged by different explosion severities are obtained by non-spatial simulation and spatial simulation respectively. It can be concluded that compared with the non-spatial model, the numerical simulation results of the spatial model are closer to the experimental situation. Therefore, inclusion of spatial variability is recommended for reliability-based blast-resistant design for UHPC column. [ABSTRACT FROM AUTHOR]