1. Prevalence of rifampicin resistant tuberculosis and associated factors among presumptive tuberculosis patients in a secondary referral hospital in Lagos Nigeria
- Author
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Kehinde O Otemuyiwa, Olusola Adedeji Adejumo, Henry Owuna, Oluwatosin Adegboye, Sunday Adesola, Victor Adepoju, Abimbola Bowale, Shafaatu N Oladega, Bolanle Olusola-Faleye, and Ayodeji Falana
- Subjects
Adult ,Male ,medicine.medical_specialty ,Tuberculosis ,Referral ,Xpert MTB/RIF ,030231 tropical medicine ,Nigeria ,Rifampicin resistance ,Polymerase Chain Reaction ,Mycobacterium tuberculosis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Tuberculosis, Multidrug-Resistant ,Prevalence ,medicine ,Humans ,030212 general & internal medicine ,Antibiotics, Antitubercular ,Tuberculosis, Pulmonary ,Aged ,Retrospective Studies ,Retrospective review ,biology ,business.industry ,Lagos ,Articles ,Sequence Analysis, DNA ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Rifampicin resistant tuberculosis ,Female ,Hiv status ,Rifampin ,Rifampicin resistance, tuberculosis, Xpert MTB/RIF, Lagos ,Previously treated ,business - Abstract
Background: Nigeria is one of the 30 high burden countries for drug resistant tuberculosis (DR-TB). This study assessed the prevalence and factors associated with rifampicin resistant tuberculosis (RR-TB) in a secondary referral hospital in Lagos State Nigeria. Methods: A retrospective review of presumptive TB register of patients screened for Mycobacterium tuberculosis (MTB) and RR-TB using Xpert MTB/RIF assay at Mainland hospital between January 1 2012 and December 31 2016 was conducted. Results: A total of 2497 clients were screened for MTB and RR-TB during the study period. The majority (51.4%) were between 25 – 44 years. Male: Female ratio was 1:0.8. Of the 2497 clients screened, MTB was detected in 942 (37.7%) out of which 220 (23.4%) had RR-TB. Age (AOR 1.8, 95%CI 1.3- 2.6, p = 0.001), symptomatic contact with DR-TB patients (AOR 3.3, 95%CI 2.1-5.1, p
- Published
- 2018
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