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The university-industry contractual research collaborations to solve complex problems jointly and create social and economic impact have long existed. Technology Transfer Offices (TTOs) constitute formal technology intermediaries established to strengthen university-industry collaborations. However, the differences in needs and capabilities, individual and organizational backgrounds, and innovative learning modes inhibit effective partnerships. We develop a conceptual framework that explains how TTOs can catalyze these collaborations in Botswana. We use the grounded theory approach to examine the TTOs' challenges and opportunities in strengthening university-industry linkages. Notably, we employ inductive analysis to synthesize interview data and analyze it using domain analysis and componential analysis. Data were extracted from the university and industry policies and documents and interviews with 102 participants from two universities (42.2%) and three industry firms (57.8%) involved in technology transfer. We found 71.6% had excellent knowledge and experience and 28.4% had varying degrees of experience. While individual or independent consultancies (44.1%) lead, TTOs facilitate collaboration through contractual research agreements (32.4%), technology licensing (22.5%), and joint ventures (10.8%). This demonstrates entities' significant access to each other's financial and technological resources. This allows entities to generate new knowledge, equip each other with tools and competencies required to produce commercial products and new revenue streams. Most significantly, while Botswana has displayed remarkable progress toward strengthening its institutional support systems for technology transfer and commercialization, there is a shortage of IP expertise at universities and industries, possibly leading to low levels of IP awareness. Also, most institutions have incomplete IP strategies, and there is inadequate administration and enforcement of intellectual property rights systems at the national level, possibly contributing to low national IP filings. Therefore, we recommend entities fully engage in vigorous IP activities, review and finalize their IP policies and make them flexible yet equitably based on the needs of the collaborating industry firms. [ABSTRACT FROM AUTHOR]