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The article discusses the historical development along with the political and economic constraints and prospects in the establishment of a concrete East African Trade Union Federation. It relates that the effort to establish transnationalization of trade unionism in developing countries was propelled by the desire to counter anti-trade union tendency that is a common practice in contemporary globalization. Moreover, it provides an overview on the development of trade unions in East Africa during the colonial period in 1908 up to the creation of a trade union confederation in 2006.