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Background and study aim: The treatment of chronic hepatitis C infection (CHC) has been revolutionized by using novel direct-acting antivirals (DAAs). Transient elastography (TE) and aspartate aminotransferase to platelet ratio index (APRI) are simple and convenient diagnostic tools for the assessment of liver fibrosis. This study was designed to evaluate liver fibrosis by using TE and APRI before and one year after a full course of DAAs therapy in cases with CHC infection. Patients and methods: TE and APRI were measured before treatment and one year after a full course of DAAs therapy in a prospective study of 82 CHC cases. All candidates with CHC infection were genotype 4. TE was measured by Fibroscan and liver stiffness measurement (LSM) was considered reliable if 10 successful LSM had been obtained with a success rate (SR) ≥ 60% and interquartile range (IQR)