1. Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease.
- Author
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Neha and Parvez, Suhel
- Subjects
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ALZHEIMER'S disease , *DRUG repositioning , *TAU proteins , *CEREBRAL cortex , *NEURODEGENERATION , *CHOLINERGIC mechanisms , *DONEPEZIL - Abstract
Alzheimer's disease (AD) is a multivariate and diversified disease and affects the most sensitive areas of the brain, the cerebral cortex, and the hippocampus. AD is a progressive age-related neurodegenerative disease most often associated with memory deficits and cognition that get more worsen over time. The central theory on the pathophysiological hallmark features of AD is characterized by the accumulation of amyloid β (Aβ) peptides, also associated with tau proteins (τ) dysfunctioning which leads to distorted microtubular structure, affects the cholinergic system, and mitochondrial biogenesis. This review emphasizes how simple it is to find novel treatments for AD and focuses on several recently developed medications through repurposing that can speed up traditional drug development. • Alzheimer's Disease is a multivariate and diversified disease • The cerebral cortex and hippocampus are frequently affected regions in AD. • The pathology of Alzheimer's Disease is characterized by the accumulation of β amyloid peptides and the dysfunctioning of tau proteins. • Recently developed medications through repurposing can speed up traditional drug development. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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