1. Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies
- Author
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Yi-Peng Han, Xingyao Tang, Marly Augusto Cardoso, Jin-Kui Yang, Min Han, Rafael Simó, Jian-Bo Zhou, Institut Català de la Salut, [Han YP, Tang X] Beijing Tongren Hospital, Capital Medical University, Beijing, China. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. [Han M] Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. [Yang J, Zhou J] Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [Cardoso MA] Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil. [Simó R] Servei d’Endocrinologia i Nutrició, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Unitat de Recerca en Diabetis i Metabolisme, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Aging ,medicine.medical_specialty ,Overweight ,técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Biochemistry ,Nervous System::Central Nervous System::Brain [ANATOMY] ,sistema nervioso::sistema nervioso central::encéfalo [ANATOMÍA] ,Body Mass Index ,Waist–hip ratio ,Cervell - Imatgeria per ressonància magnètica ,Risk Factors ,Internal medicine ,Malalties - Factors de risc ,Epidemiology ,medicine ,Humans ,Obesity ,Prospective Studies ,Molecular Biology ,Other subheadings::Other subheadings::/diagnostic imaging [Other subheadings] ,medicine.diagnostic_test ,business.industry ,Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [DISEASES] ,nutritional and metabolic diseases ,Brain ,Magnetic resonance imaging ,Otros calificadores::Otros calificadores::/diagnóstico por imagen [Otros calificadores] ,medicine.disease ,Cross-Sectional Studies ,Neurology ,Brain size ,enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad [ENFERMEDADES] ,Obesitat ,Observational study ,Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,medicine.symptom ,Waist Circumference ,business ,Body mass index ,Biotechnology - Abstract
Body mass index; Structural brain abnormalities Índex de massa corporal; Anormalitats estructurals del cervell Índice de masa corporal; Anomalías estructurales del cerebro We aimed to evaluate the relationship between obesity and structural brain abnormalities assessed by magnetic resonance imaging using data from 45 observational epidemiological studies, where five articles reported prospective longitudinal results. In cross-sectional studies’ analyses, the pooled weighted mean difference for total brain volume (TBV) and gray matter volume (GMV) in obese/overweight participants was -11.59 (95 % CI: -23.17 to -0.02) and -10.98 (95 % CI: -20.78 to -1.18), respectively. TBV was adversely associated with BMI and WC, GMV with BMI, and hippocampal volume with BMI, WC, and WHR. WC/WHR are associated with a risk of lacunar and white matter hyperintensity (WMH). In longitudinal studies’ analyses, BMI was not statistically associated with the overall structural brain abnormalities (for continuous BMI: RR = 1.02, 95 % CI: 0.94–1.12; for categorial BMI: RR = 1.18, 95 % CI: 0.75–1.85). Small sample size of prospective longitudinal studies limited the power of its pooled estimates. A higher BMI is associated with lower brain volume while greater WC/WHR, but not BMI, is related to a risk of lacunar infarct and WMH. Future longitudinal research is needed to further elucidate the specific causal relationships and explore preventive measures. This work was supported by the National Natural Science Foundation of China (No. 82070851, 81870556, 81930019, 81770686, 81970591), Beijing Municipal Administration of Hospital’s Youth Program (QML20170204), Excellent Talents in Dongcheng District of Beijing.
- Published
- 2020