1. Leukocyte adhesion and the anti-inflammatory effects of leukocyte integrin blockade.
- Author
-
Issekutz TB
- Subjects
- Animals, Cell Adhesion Molecules physiology, Cell Movement physiology, Humans, Integrins metabolism, Mucins physiology, Sialomucins, Inflammation physiopathology, Integrins antagonists & inhibitors, Leukocyte Migration-Inhibitory Factors physiology, Leukocytes metabolism
- Abstract
The past several years have produced a dramatic increase in our understanding of the steps involved in the infiltration of leukocytes into inflamed tissues. At least four major families of adhesion molecules: the selectins, sialomucins, integrins, and Ig supergene family CAMs have been identified; and their interactions are being elucidated. The role of the leukocyte beta 2 and alpha 4 integrins and the selective use of these integrins by leukocytes for migration into inflamed tissues in various organs is presented.
- Published
- 1995
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