1. Inflammatory bowel disease as a new risk factor for dementia
- Author
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Marco Zuin, Roberto De Giorgio, Eleonora Capatti, Elisa Boschetti, and Giovanni Zuliani
- Subjects
Male ,Aging ,Crohn Disease ,Risk Factors ,Chronic Disease ,Humans ,Colitis, Ulcerative ,Dementia ,Female ,Geriatrics and Gerontology ,Inflammatory Bowel Diseases - Abstract
The prognostic impact of inflammatory bowel disease (IBD), chronic inflammatory conditions consisting of ulcerative colitis (UC), and Crohn's disease (CD) on the risk of dementia has been poorly investigated. We evaluated the risk of dementia in IBD patients by a systematic review and meta-analysis of the available data. Three studies, enrolling 121.827 patients [14.839 IBD (12.1%) and 106.961 (87.7%) controls, respectively] were included in the analysis. Of these, 57.7% (n = 8.571) had UC, while 42.2% (n = 6268) had CD. The mean follow-up period was 21.3 years. A random effect model revealed an aHR of 1.52 (95% CI 1.04-2.020, p = 0.01; I
- Published
- 2021