1. Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19.
- Author
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Ragusa FS, Solimando L, Mandalà C, Masnata R, Ciulla G, Ciriminna S, La Blasca F, Mansueto P, Veronese N, and Barbagallo M
- Subjects
- Male, Humans, Aged, Female, Prognosis, Hospitals, Geriatric Assessment methods, Frailty diagnosis, Frailty epidemiology, COVID-19 epidemiology
- Abstract
Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens., Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months., Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics., Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
- Published
- 2023
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