1. Combined use of teriparatide and TNFalpha blockade: safety.
- Author
-
Migliore A, Massafra U, Capuano A, and Martin SM
- Subjects
- Aged, Aged, 80 and over, Anti-Inflammatory Agents adverse effects, Antibodies, Monoclonal adverse effects, Arthritis, Rheumatoid drug therapy, Bone Density Conservation Agents adverse effects, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Infliximab, Osteoporosis drug therapy, Teriparatide adverse effects, Treatment Outcome, Tumor Necrosis Factor-alpha antagonists & inhibitors, Anti-Inflammatory Agents administration & dosage, Antibodies, Monoclonal administration & dosage, Bone Density Conservation Agents administration & dosage, Spondylarthritis drug therapy, Teriparatide administration & dosage
- Abstract
Up to now, there have been no reports about the combined use of Teriparatide and Anti- TNFalpha blockers in patients affected by inflammatory bone diseases and osteoporosis. In this report, we evaluate the safety of the combined therapeutic use of Teriparatide and Anti-TNFalpha drugs in patients with inflammatory arthritis and severe osteoporosis. Six female patients were selected and treated with biological therapy (3 patients with Etanercept, 3 with Infliximab) for arthritis (2 RA, 4 SPA), having suffered at least 2 vertebral fragility fractures. The mean T-score value, tested by DEXA densitometry, was -2.8 SD - diagnostic for osteoporosis according to WHO criteria. All patients were treated with Teraparatide s.c. (20 microg daily), together with 1200 mg of calcium and 800 IU of vitamin D daily. Until the present time, we have observed no side-effects or therapeutic discontinuity. During the 9-month follow-up period, we did not observe any new symptomatic fractures or infections in treated patients, but we found a reduction in parameters indicating inflammation; no differences were found in biochemical parameters.
- Published
- 2007