1. The association between metabolic syndrome and benign prostatic hyperplasia: a systematic review and meta-analysis.
- Author
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Li, Jinze, Peng, Lei, Cao, Dehong, Gou, Haocheng, Li, Yunxiang, and Wei, Qiang
- Subjects
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BENIGN prostatic hyperplasia , *RETENTION of urine , *METABOLIC syndrome , *PROSTATE , *META-analysis , *URINATION , *SYSTEMATIC reviews , *TREATMENT effectiveness , *QUALITY of life - Abstract
Objective: We performed this meta-analysis to assess the association between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH).Method: We conducted extensive searches on the PubMed, Science and Cochrane Library to identify all articles. Outcomes including annual prostate growth rate, prostate volume (PV), International Prostate Symptom Score (IPSS), IPSS sub-scores (voiding and storage), prostate- specific antigen (PSA), maximum urine flow rate (Qmax), post-void residual urine volume (PVR) and quality of life (QoL) were assessed.Results: 21 studies with 15,317 patients were included. Patients with MetS had higher annual prostate growth rate [weighted mean difference (WMD) = 0.79; p < .001], larger PV (WMD = 2.62; p < .001), lower Qmax (WMD = -0.48; p = .001) and more PVR (WMD = 8.28; p < .001). However, no significant differences were found between two groups in IPSS (WMD = 0.20; p = .37), IPSS-voiding (WMD = -0.05; p = .78), IPSS-storage (WMD = -0.22; p = .26), PSA (WMD = 0.04; p = .43), and QoL (WMD = -0.01; p = .70).Conclusions: The study suggested that MetS may be one of the risk factors for the clinical progress of BPH. However, further study is warranted to support these results. [ABSTRACT FROM AUTHOR]- Published
- 2020
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