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The coupling coordination of agricultural technology innovation with food security is of great significance for high-quality agricultural development. By identifying the coupling coordination relationship between the two systems and the influencing factors, this paper aims to promote the virtuous cycle of coordinated development between regional agriculture and technology, as well as accelerate the realisation of high-quality development of Chinese agriculture. Therefore, this paper explores the spatial and temporal coupling characteristics of the two using the entropy value method, coupling coordination degree model, and exploratory spatial data analysis, and it screens for important influencing factors using the grey correlation model. The main results show that ① the coupling coordination relationship between agricultural technology innovation and food security in China is at a dissonant stage, but the value of the coupling coordination degree increases from 0.2076 to 0.3437 during the period of study, and the level of coordination gradually improves. ② The degree of coupling coordination in the provincial space exhibits a distribution pattern of "high in the east and low in the west". The areas of high value are primarily situated in the provinces of Shandong, Jiangsu, and other provinces along the southeastern coast of China, while the areas of low value are mainly located in the provinces of Qinghai, Ningxia, and other provinces in inland northwest China. ③ The Moran's index of provincial coupling coordination is greater than 0, showing a certain positive correlation, and there is a significant pattern of spatial aggregation. ④ The correlation coefficients between the influencing factors and the degree of coupling coordination are all greater than 0.35, indicating a moderate or high correlation, but the significance of technological support capacity and food distribution security increased over time. [ABSTRACT FROM AUTHOR]