Lime application combined with complementary sustainable management practices increases crop yields, but liming is only modestly applied in Serbia. This study investigated the influence of liming (1000 kg/ha) combined with the common application of mineral fertilizers on maize yield and the chemical properties of pseudogley soil. The experiment was conducted near Kraljevo, Western Serbia, on the maize hybrid ZP 606 sown in a two-year monoculture. The experiment had three treatments: fertilizer, fertilizer + lime, and a control treatment. The soil is acid, poor in humus, and contains an increased content of mobile aluminum. There was a significant increase in yield under the fertilizer and lime + fertilizer treatments, compared to the control. The yield of maize in the limed treatment was 4.4–9% higher than in the fertilizer treatment. The positive effects of liming on soil are related to an increase in pH, base saturation, and available phosphorus, and a decrease in available aluminum. In the fertilizer treatment, there was a small decrease in pH and base saturation, whereas the amount of aluminum remained high, indicating that the further application of fertilizers without lime can increase aluminum content and foster its toxicity. The long-term sustainability of maize production in Serbia should include liming as a regular management practice on pseudogley soil, with the utilization of smaller doses of lime because of the potential CO2 effects. To improve soil health, food, and environmental security, and to incorporate new crops, developing a framework promoting liming as a sustainable management practice is of high importance. [ABSTRACT FROM AUTHOR]