In this article, traditional supply chain planning models are extended to simultaneously optimize inventory policies. The inventory policies considered are the (r,Q) and (s,S) policies. In the (r,Q) inventory policy an order for Q units is placed every time the inventory level reaches level r, while in the s,S policy the inventory is reviewed in predefined intervals. If the inventory is found to be below level s, an order is placed to bring the level back to level S. Additionally, to address demand uncertainty four safety stock formulations are presented: (1) proportional to throughput, (2) proportional to throughput with risk‐pooling effect, (3) explicit risk‐pooling, and (4) guaranteed service time. The models proposed allow simultaneous optimization of safety stock, reserve, and base stock levels in tandem with material flows in supply chain planning. The formulations are evaluated using simulation. © 2018 American Institute of Chemical Engineers AIChE J, 65: 99–112, 2019 [ABSTRACT FROM AUTHOR]