1. Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae
- Author
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Jodi Pongoski, Scott D. Gray-Owen, Adrienne Chen, Alan Cochrane, and Ian C. Boulton
- Subjects
CD4-Positive T-Lymphocytes ,Sexually transmitted disease ,Transcription, Genetic ,Immunology ,HIV Infections ,Biology ,medicine.disease_cause ,Jurkat cells ,Microbiology ,Gonorrhea ,Jurkat Cells ,medicine ,Humans ,Immunology and Allergy ,Viral shedding ,Seroconversion ,HIV Long Terminal Repeat ,biology.organism_classification ,Virology ,Neisseria gonorrhoeae ,Long terminal repeat ,Infectious Diseases ,Lentivirus ,HIV-1 - Abstract
Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.
- Published
- 2003
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