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2 results on '"Alain Sobel"'

1. Failure to maintain long-term adherence to highly active antiretroviral therapy: the role of lipodystrophy

Author

Catherine Leport, Dominique Salmon, Valérie Cailleton, Jean-Paul Moatti, Patrizia Carrieri, Marianne Savès, Bruno Spire, Ségolène Duran, and Alain Sobel

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Lipodystrophy, medicine.medical_treatment, Immunology, HIV Infections, Cohort Studies, Acquired immunodeficiency syndrome (AIDS), Antiretroviral Therapy, Highly Active, Surveys and Questionnaires, Immunopathology, Internal medicine, medicine, Humans, Immunology and Allergy, Risk factor, Sida, Chemotherapy, biology, business.industry, Middle Aged, biology.organism_classification, medicine.disease, Surgery, Regimen, Infectious Diseases, Patient Compliance, Female, business, Cohort study
Abstract

In a sample of 277 patients included in the French APROCO cohort study who were initially adherent at follow-up visit 4 months after initiation of a protease inhibitor-containing regimen, 76.4% self-reported at least one lipodystrophy-related symptom and 30.0% failed to maintain adherence behaviour 20 months after enrolment. After multiple adjustment for other related factors, such as younger age, alcohol consumption and poor housing conditions, the number of self-reported lipodystrophy symptoms was independently associated with adherence failure.

Published
2001

2. Zidovudine therapy and HIV encephalitis

Author

Catherine Keohane, Françoise Gray, M. Durigon, Alain Sobel, Bernard Clair, Laurent Bélec, Pierre De Truchis, and Romain K. Gherardi

Subjects
Adult, Male, Sexually transmitted disease, Pediatrics, medicine.medical_specialty, AIDS Dementia Complex, Immunology, Neuropathology, Zidovudine, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, Immunology and Allergy, Sida, biology, business.industry, Incidence, Incidence (epidemiology), Brain, Middle Aged, biology.organism_classification, medicine.disease, Virology, Infectious Diseases, Encephalitis, Female, Viral disease, business, medicine.drug
Abstract

To assess the effect of zidovudine on productive HIV infection of the brain.To correlate the incidence of HIV-specific neuropathology with zidovudine therapy.We examined 192 AIDS cases neuropathologically; 97 had never been treated with zidovudine, 72 had received zidovudine for over 3 months and until death, 23 had their treatment terminated more than 1 month before death.The incidence of HIV encephalitis/HIV leukoencephalopathy (HIVE/HIVL) and of multinucleated giant cells (MGC) was significantly lower in patients who had received zidovudine than in those who had never received zidovudine. The yearly incidence of HIVE/HIVL increased between 1982 and 1987 probably because of improved survival, and decreased between 1987 and 1990 although the percentage of patients treated with zidovudine increased. Since 1991 the incidence of HIVE/HIVL and of MGC increased slightly. The percentage of patients treated with zidovudine until death decreased and that of patients whose treatment was terminated increased concomitantly. In 1989 and 1990, most patients whose treatment was terminated had MGC and HIVE/HIVL. In 1991 and 1992 this incidence decreased markedly, coinciding with the introduction of dideoxyinosine therapy.Zidovudine treatment significantly reduces the occurrence of productive HIV infection of the brain in AIDS. Discontinuing zidovudine therapy may favour the occurrence of HIV encephalitis. Substitution therapy with dideoxyinosine also appears to protect against HIV-specific brain pathology.

Published
1994

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