1. Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients
- Author
-
Ponnambalam Annapoorani, Andiappan Rathinavel, Manjeet Singh, Perundurai S. Dhandapany, Reghunath Omnath, Govindan Sadasivam Selvam, Perumal Kannan, Pitchai Balakumar, Rajagopalan Ganesh, and Subbiah Ramasamy
- Subjects
Gene isoform ,Pathology ,medicine.medical_specialty ,Heart Diseases ,Heart disease ,Blotting, Western ,Immunology ,Alpha (ethology) ,Enzyme-Linked Immunosorbent Assay ,HIV Infections ,Sensitivity and Specificity ,Western blot ,Acquired immunodeficiency syndrome (AIDS) ,Immunopathology ,medicine ,Humans ,Protein Isoforms ,Immunology and Allergy ,alpha-Macroglobulins ,Sida ,medicine.diagnostic_test ,biology ,business.industry ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Case-Control Studies ,Viral disease ,business ,Biomarkers - Abstract
This study investigated the possible role of the cardiac isoform of alpha 2-macroglobulin (CA2M) as an early diagnostic marker for HIV-associated cardiovascular manifestations. A total of 349 samples were analysed by Western blot and quantified by sandwich enzyme-linked immunosorbent assay. The levels of CA2M present in sera of HIV-associated cardiac diseases were significantly higher than those of HIV without cardiac involvement and healthy sera. CA2M may act as a novel diagnostic marker to identify cardiac manifestations in HIV/AIDS patients.
- Published
- 2006
- Full Text
- View/download PDF