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14 results on '"Ribaudo, Heather J"'

1. Hepatic steatosis and nonalcoholic fatty liver disease are common and associated with cardiometabolic risk in a primary prevention cohort of people with HIV

Author

Lake, Jordan E., Taron, Jana, Ribaudo, Heather J., Leon-Cruz, Jorge, Utay, Netanya S., Swaminathan, Shobha, Fitch, Kathleen V., Kileel, Emma M., Paradis, Kayla, Fulda, Evelynne S., Ho, Ken S., Luetkemeyer, Anne F., Johnston, Carrie D., Zanni, Markella V., Douglas, Pamela S., Grinspoon, Steven K., Lu, Michael T., and Fichtenbaum, Carl J.

Published
2023
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2. A prospective, randomized clinical trial of antiretroviral therapies on carotid wall thickness

Author

Stein, James H, Ribaudo, Heather J, Hodis, Howard N, Brown, Todd T, Tran, Thuy Tien T, Yan, Mingzhu, Brodell, Elizabeth Lauer, Kelesidis, Theodore, McComsey, Grace A, Dube, Michael P, Murphy, Robert L, and Currier, Judith S

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Trials and Supportive Activities, Clinical Research, HIV/AIDS, Cardiovascular, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Adult, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, Carotid Arteries, Carotid Artery Diseases, Carotid Intima-Media Thickness, Female, HIV Infections, HIV-1, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, antiretroviral therapy, atherosclerosis, cardiovascular disease, carotid arteries, HIV, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveThis article compares the effects of initiating three contemporary antiretroviral therapy (ART) regimens on progression of carotid artery intima-media thickness (IMT) over 3 years.DesignRandomized clinical trial.SettingMulticenter (26 institutions).PatientsART-naive HIV-infected individuals (n = 328) without known cardiovascular disease or diabetes mellitus.InterventionRandom assignment to tenofovir/emtricitabine along with atazanavir/ritonavir (ATV/r), darunavir/ritonavir (DRV/r), or raltegravir (RAL).Main outcome measuresRight-sided carotid IMT was evaluated by B-mode ultrasonography before ART initiation, and then after 48, 96, and 144 weeks. Comparisons of yearly rates of change in carotid IMT used mixed-effects linear regression models that permitted not only evaluation of the effects of ART on carotid IMT progression but also how ART-associated changes in traditional risk factors, bilirubin, and markers of HIV infection were associated carotid IMT progression.ResultsHIV-1 RNA suppression rates were high in all arms (>85%) over 144 weeks. Modest increases in triglycerides and non-high-density lipoprotein cholesterol levels were observed in the protease inhibitor-containing arms compared with decreases with RAL. In contrast, carotid IMT progressed more slowly on ATV/r [8.2, 95% confidence interval (5.6, 10.8) μm/year] than DRV/r [12.9 (10.3, 15.5) μm/year, P = 0.013]; changes with RAL were intermediate [10.7 (9.2, 12.2) μm/year, P = 0.15 vs. ATV/r; P = 0.31 vs. DRV/r]. Bilirubin and non-high-density lipoprotein cholesterol levels appeared to influence carotid IMT progression rates.ConclusionIn ART-naive HIV-infected individuals at low cardiovascular disease risk, carotid IMT progressed more slowly in participants initiating ATV/r than those initiating DRV/r, with intermediate changes associated with RAL. This effect may be due, in part, to hyperbilirubinemia.

Published
2015

3. Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV

Author

Douglas, Pamela S., primary, McCallum, Sara, additional, Lu, Michael T., additional, Umbleja, Triin, additional, Fitch, Kathleen V., additional, Foldyna, Borek, additional, Zanni, Markella V., additional, Fulda, Evelynne S., additional, Bloomfield, Gerald S., additional, Fichtenbaum, Carl J., additional, Overton, Edgar T., additional, Aberg, Judith A., additional, Malvestutto, Carlos D., additional, Burdo, Tricia H., additional, Arduino, Roberto C., additional, Ho, Ken S., additional, Yin, Michael T., additional, Ribaudo, Heather J., additional, and Grinspoon, Steven K., additional

Published
2022
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4. Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk

Author

Fitch, Kathleen V., primary, McCallum, Sara A., additional, Erlandson, Kristine M., additional, Overton, Edgar Turner, additional, Zanni, Markella V., additional, Fichtenbaum, Carl, additional, Aberg, Judith A., additional, Fulda, Evelynne S., additional, Kileel, Emma M., additional, Moran, Laura E., additional, Bloomfield, Gerald S., additional, Novak, Richard M., additional, Pérez-Frontera, Sigrid, additional, Abrams-Downey, Alexandra, additional, Pierone, Gerald, additional, Kumarasamy, Nagalingeswaran, additional, Ruxrungtham, Kiat, additional, Mngqibisa, Rosie, additional, Douglas, Pamela S., additional, Ribaudo, Heather J., additional, and Grinspoon, Steven K., additional

Published
2022
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7. Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV

Author

Douglas, Pamela S., McCallum, Sara, Lu, Michael T., Umbleja, Triin, Fitch, Kathleen V., Foldyna, Borek, Zanni, Markella V., Fulda, Evelynne S., Bloomfield, Gerald S., Fichtenbaum, Carl J., Overton, Edgar T., Aberg, Judith A., Malvestutto, Carlos D., Burdo, Tricia H., Arduino, Roberto C., Ho, Ken S., Yin, Michael T., Ribaudo, Heather J., and Grinspoon, Steven K.

Published
2023
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