1. General and abdominal obesity and incident hypertension among people living with HIV on antiretroviral therapy.
- Author
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Xu, Xiaohui, Chen, Xiaoxiao, Lin, Haijiang, Zhu, Bowen, Shen, Weiwei, Shi, Ruizi, Xu, Xiaoyi, He, Na, and Ding, Yingying
- Subjects
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HIV-positive persons , *OBESITY , *HYPERTENSION , *ANTIRETROVIRAL agents , *HIGHLY active antiretroviral therapy , *WAIST circumference , *STATISTICAL models , *ODDS ratio , *LONGITUDINAL method - Abstract
Hypertension is highly prevalent among people living with HIV (PLWH). We sought to characterize the hypertension incidence among PLWH on antiretroviral therapy, focusing on the effect of change in general and abdominal obesity on hypertension during follow-up. This was a prospective analysis of 229 treated PLWH aged over 40 years without hypertension at baseline. Overall a median follow-up of 2.9 years, 26.2% PLWH developed hypertension. In multivariable models, compared to those without obesity measures at both baseline and follow-up visit, PLWH with general obesity at both occasions (adjusted odds ratio [aOR] = 3.83, P = 0.006) or at baseline only (aOR = 5.45, P = 0.003), abdominal obesity (measured as waist circumference) at both occasions (aOR = 3.87, P = 0.001) or at follow-up only (aOR = 2.27; 9P = 0.060), abdominal obesity (measured as waist-to-hip ratio) at both occasions (aOR = 2.27, P = 0.077) were at increased risk of incident hypertension. Our data show that both general and abdominal obesity especially in the persistent status increase the hypertension risk in treated PLWH. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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