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1. Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy.

Author

Damås JK, Landrø L, Fevang B, Heggelund L, Frøland SS, and Aukrust P

Subjects
Adult, Antiretroviral Therapy, Highly Active, Cross-Sectional Studies, Disease Progression, Female, HIV Infections drug therapy, HIV Infections virology, Humans, Longitudinal Studies, Male, Treatment Outcome, Viral Load, Young Adult, Chemokine CCL19 blood, Chemokine CCL21 blood, HIV Infections immunology
Abstract

The CCR7 ligands, CCL19 and CCL21, coordinate lymph node homing of naive and central memory T cells. In untreated HIV-infected patients, serum levels of CCL19 and CCL21 showed a biphasic pattern during progression; a marked increase was followed by a decline in patients with advanced immunodeficiency. During highly active antiretroviral therapy, a decrease in CCL19/CCL21 levels was restricted to virologic responders. We suggest that dysregulation of CCR7 ligands may play an important role in progression of HIV infection.

Published
2009
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