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Your search keyword '"Smit Erasmus"' showing total 5 results
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5 results on '"Smit Erasmus"'

1. First reported case of integrase (R263K, G163R) and reverse transcriptase (M184V)-transmitted drug resistance from a drug-naive patient failing Triumeq.

Author

Cochrane S, Daniel J, Forsyth S, and Smit E

Subjects
Adult, Anti-HIV Agents therapeutic use, Dideoxynucleosides pharmacology, Dideoxynucleosides therapeutic use, Drug Combinations, Female, HIV genetics, HIV isolation & purification, HIV Infections drug therapy, HIV Infections virology, Heterocyclic Compounds, 3-Ring pharmacology, Heterocyclic Compounds, 3-Ring therapeutic use, Humans, Lamivudine pharmacology, Lamivudine therapeutic use, Treatment Failure, Anti-HIV Agents pharmacology, Drug Resistance, Viral, HIV drug effects, HIV Infections transmission, HIV Integrase genetics, HIV Reverse Transcriptase genetics, Mutation, Missense
Published
2018
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2. Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Author

Taylor S, Jayasuriya AN, Berry A, Gilleran G, Dufty NE, Else L, Back DJ, and Smit EJ

Subjects
Adult, Darunavir, Drug Resistance, Microbial, HIV Infections blood, Humans, Male, Middle Aged, Anti-HIV Agents metabolism, HIV Infections drug therapy, HIV-1 metabolism, Semen virology, Sulfonamides metabolism
Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

Published
2010
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4. Stopping antiretroviral therapy.

Author

Taylor S, Boffito M, Khoo S, Smit E, and Back D

Subjects
Anti-HIV Agents blood, Antiretroviral Therapy, Highly Active methods, Drug Administration Schedule, Evidence-Based Medicine, HIV Infections blood, HIV Infections virology, Half-Life, Humans, Viral Load, Anti-HIV Agents administration & dosage, HIV Infections drug therapy
Published
2007
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