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To improve the quality of fused deposition molding (FDM), we introduced ultrasonic vibration into the molding process to enhance the strength of the tensile samples. We used the response surface method to optimize the FDM molding process. We carried out orthogonal experiments to investigate the effects of ultrasonic power and process parameters (extrusion temperature, hotbed temperature, and delamination thickness) on the mechanical properties of fused deposition acrylonitrile butadiene styrene products. We obtained the quadratic regression equations and response surfaces of the data through analysis of variance and significance analysis by software. Last, we received the optimum combination of process parameters for tensile strength as extrusion temperature 233.85 °C, hotbed temperature 93.38 °C, delamination thickness 0.1 mm, and ultrasonic power 43.09 W. [ABSTRACT FROM AUTHOR]