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The Indian subcontinent has probably the most elevated pace of oral malignant growth on the planet. 65% of all malignant growth in men and 33% of all diseases in ladies are tobacco related. It is assessed that approximately 1,000,000 individuals die because of tobacco related illnesses in India every year. It is essential that numerous oral squamous cell carcinomas transform from conceivably harmful issues such as oral potentially malignant disorders (OPMDs). Zingiber officinale has been used since long for their mitigating properties, notwithstanding and has been used to treat inflammation as it inhibits cyclooxygenase. There is data in regards to the distinguishing proof of gingerol-related mixtures that have mitigating movement through the particular hindrance of COX-2. Our main objective was to formulate a cellulose based muccoadhesive films impregnated with small dose of zingibain for management of OPMDs to guarantee prolonged retention of the medicament on to the oral mucosa for better treatment outcome. The mucoadhesive buccal patch would not only retain the medicament for a longer period, but will also act as a muco-protective barrier for faster wound healing. The present paper would be describing the potential application of Zingibain containing mucoadhesive buccal patch for an effective non-surgical management of OPMDs. [ABSTRACT FROM AUTHOR]