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In this work, Ag and Fe3O4 NPs embedded and P(Nipam) coated mesoporous silica (mSiO2@Ag-Fe3O4@P(Nipam) NC) based magnetically controllable and thermoresponsive nanocomposite has been synthesized and characterized for structural, microstructural and magnetic properties. First, mSiO2-Ag-Fe3O4 NC was prepared by simple sol gel process using Ag NPs, Fe3O4 NPs, TEOS, and CTAB. mSiO2@Ag-Fe3O4@P(Nipam) NC was prepared by in situ coating of P(Nipam) on the surface of mSiO2@Ag-Fe3O4 in the presence of oxidizer and crosslinker. TEM and FTIR analysis confirm the presence of AgNPs and Fe3O4 NPs in silica nanosphere and reveal the coating of P(Nipam) polymer. This smart nanocomposite could be very useful as intelligent antimicrobial agent and for targeted chemo-photothermal therapy. [ABSTRACT FROM AUTHOR]

In this work two different sizes of Fe3O4 nanoparticles (NPs) have successfully been synthesized by changing reaction parameter. Prepared Fe3O4 NPs have been characterized for its structural, morphological, and magnetic properties by using XRD, FESEM, TEM, SAED and VSM techniques. XRD and SAED patterns confirmed the formation of cubic phase Fe3O4 NPs. Crystallite sizes estimated using the Debye-Scherrer equation of both prepared Fe3O4 NPs using less (S1) and more (S2) NaBH4 were found to be ~9 and ~18 nm respectively. Both TEM and FESEM results suggested nearly spherical and random morphology of both S1 and S2 prepared Fe3O4 NPs with average particles sizes of 22 and 27 nm respectively. VSM result revealed superparamagnetic nature of the prepared Fe3O4 NPs. In the last section of this work, prepared Fe3O4 NPs have successfully been coated with albumen to form biocompatible multifunctional Fe3O4@Alb nanoparticle. These Fe3O4@Alb NPs may find potential applications in targeted drug delivery due to its magnetic tunability, biocompatibility and inexpensiveness. [ABSTRACT FROM AUTHOR]